Grape seed extract contains several plant compounds, including oligomeric proanthocyanidins, or OPCs. OPCs are powerful antioxidants. Protects the skin from sun damage will maintain, or improve, the overall appearance of the skin. There’s strong evidence that grape seed extract is beneficial for a number of cardiovascular conditions. Grape seed extract may help with a type of poor circulation (chronic venous insufficiency) and high cholesterol. Grape seed extract also reduces swelling caused by injury and helps with eye disease related to diabetes.